Motif ID: MEF2{A,B,C,D}.p2

Z-value: 1.311


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Dchr1_-_1564603900.613.6e-04Click!
MEF2Bchr19_-_19281090,
chr19_-_19281062
0.461.1e-02Click!
MEF2Achr15_+_100106214-0.291.2e-01Click!
MEF2Cchr5_-_881196040.144.6e-01Click!
MEF2BNB-MEF2Bchr19_-_19303222-0.086.6e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_41742666 6.722 NM_002192
INHBA
inhibin, beta A
chr1_-_153029987 4.988 NM_005988
SPRR2A
small proline-rich protein 2A
chr10_+_118187381 4.300 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr1_-_153067000 4.132 NM_001024209
SPRR2E
small proline-rich protein 2E
chr1_+_84630575 4.076 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr1_-_153013593 3.182 NM_006945
SPRR2D
small proline-rich protein 2D
chr3_-_42843217 3.164


chr18_+_29027731 3.114 NM_001944
DSG3
desmoglein 3
chr1_+_151032683 2.772 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 2.761 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032866 2.727 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_-_153085963 2.712 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr12_+_8975149 2.673 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr2_-_31352489 2.644 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr2_-_211168315 2.638 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr12_+_15699277 2.553 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_+_152486977 2.443 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr12_+_119616594 2.393 NM_014365
HSPB8
heat shock 22kDa protein 8
chr13_-_60325073 2.353


chr8_-_6735438 2.170 NM_005218
DEFB1
defensin, beta 1
chr7_+_143013218 2.118 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr5_+_92918924 1.976 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr9_+_75136716 1.912 NM_138691
TMC1
transmembrane channel-like 1
chr9_+_116356199 1.839 NM_144489
RGS3
regulator of G-protein signaling 3
chr6_+_34204928 1.832 HMGA1
high mobility group AT-hook 1
chr3_+_50316517 1.770 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr1_+_90098643 1.767 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr9_+_116356407 1.744 RGS3
regulator of G-protein signaling 3
chr1_+_152956563 1.732 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr7_+_18126543 1.720 NM_001204144
HDAC9
histone deacetylase 9
chr17_+_7942351 1.719 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr21_+_30517897 1.685 C21orf7
chromosome 21 open reading frame 7
chr2_-_190044330 1.682 NM_000393
COL5A2
collagen, type V, alpha 2
chr19_+_45281125 1.650 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr20_+_58251715 1.650 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr5_+_150399980 1.644 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr10_-_3827418 1.635 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr10_-_75401199 1.633 MYOZ1
myozenin 1
chr14_+_39735871 1.617 CTAGE5
CTAGE family, member 5
chr6_+_25727004 1.604 NM_170610
HIST1H2BA
histone cluster 1, H2ba
chr12_+_105153258 1.603 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr10_-_3827205 1.591 KLF6
Kruppel-like factor 6
chr4_-_143767603 1.526 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr1_-_150693321 1.517 NM_001199829
NM_032132
HORMAD1

HORMA domain containing 1

chr1_-_152131703 1.515 NM_001122965
RPTN
repetin
chr5_-_39203061 1.510 FYB
FYN binding protein
chr9_+_105757592 1.491 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr7_+_18535351 1.489 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr14_-_53162418 1.473 NM_014584
ERO1L
ERO1-like (S. cerevisiae)
chr4_-_47983430 1.440 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr19_-_51487070 1.436 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr6_+_74405764 1.417 CD109
CD109 molecule
chr1_+_151032150 1.370 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr19_+_42212612 1.366 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr13_-_46756291 1.353 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_42212525 1.345 NM_004363
CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr5_+_150400132 1.341 GPX3
glutathione peroxidase 3 (plasma)
chr17_-_74483806 1.335 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr10_+_32856650 1.335 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr7_+_48128225 1.313 NM_181597
UPP1
uridine phosphorylase 1
chr11_+_129245834 1.312 NM_003658
BARX2
BARX homeobox 2
chr4_-_155312448 1.288 NM_017639
DCHS2
dachsous 2 (Drosophila)
chr10_-_14372807 1.282 NM_018027
FRMD4A
FERM domain containing 4A
chr20_+_30326903 1.273 NM_012112
TPX2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr18_+_61254533 1.270 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr9_+_5450455 1.266 NM_014143
CD274
CD274 molecule
chr11_-_66639602 1.251


chr7_+_80231503 1.237 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr17_-_9694613 1.198 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr10_-_75401492 1.182 NM_021245
MYOZ1
myozenin 1
chr2_-_190927321 1.157 NM_005259
MSTN
myostatin
chr17_+_40703983 1.152 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr22_+_30792929 1.151 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr19_+_42212534 1.125 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr9_+_116327301 1.119 NM_134427
RGS3
regulator of G-protein signaling 3
chr6_-_131321868 1.118 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr17_+_34538464 1.111 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr1_+_209878135 1.106 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr21_-_36252872 1.095 RUNX1
runt-related transcription factor 1
chr9_+_5231401 1.082 NM_002195
INSL4
insulin-like 4 (placenta)
chr17_-_2966900 1.072 NM_014566
OR1D5
olfactory receptor, family 1, subfamily D, member 5
chr8_+_104831415 1.064 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr13_-_46756326 1.060 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_74405909 1.059 CD109
CD109 molecule
chr4_-_76944585 1.046 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_+_74405856 1.046 CD109
CD109 molecule
chr17_-_39211462 1.030 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr9_+_131182690 1.029 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr5_-_39270708 1.022 NM_001243093
FYB
FYN binding protein
chr18_+_12407894 1.013 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chrX_-_107682600 1.009 NM_001847
COL4A6
collagen, type IV, alpha 6
chr11_-_58343308 1.005 NM_004811
LPXN
leupaxin
chr10_-_91405320 1.005 NM_148977
PANK1
pantothenate kinase 1
chr7_+_129906702 1.003 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr15_-_89764809 1.002 NM_000326
RLBP1
retinaldehyde binding protein 1
chr5_+_34839268 0.993 NM_144725
TTC23L
tetratricopeptide repeat domain 23-like
chr19_+_33072087 0.989 NM_004708
PDCD5
programmed cell death 5
chr14_-_65409445 0.978 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr13_+_109281569 0.970 NM_001198950
MYO16
myosin XVI
chr3_+_135741576 0.926 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr1_+_63063186 0.926 NM_014495
ANGPTL3
angiopoietin-like 3
chr17_+_34640030 0.919 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr1_+_179560747 0.918 NM_001199091
NM_001199085
NM_173533
TDRD5


tudor domain containing 5


chr11_-_88796815 0.917 NM_000842
GRM5
glutamate receptor, metabotropic 5
chr4_-_80329354 0.917 NM_033214
GK2
glycerol kinase 2
chr2_+_201473942 0.912 AOX1
aldehyde oxidase 1
chr7_+_142457318 0.912 NM_002769
PRSS1
PRSS2
protease, serine, 1 (trypsin 1)
protease, serine, 2 (trypsin 2)
chr1_-_115238091 0.908 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr10_+_124030820 0.907 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr14_-_53162370 0.905 ERO1L
ERO1-like (S. cerevisiae)
chr19_+_7049349 0.894 NM_144614
MBD3L2
methyl-CpG binding domain protein 3-like 2
chr13_-_46756295 0.891 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_28124915 0.889 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr9_-_104145800 0.889 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr15_-_99057610 0.887 NM_182562
FAM169B
family with sequence similarity 169, member B
chr21_+_39628869 0.885 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr2_-_163099877 0.875 NM_004460
FAP
fibroblast activation protein, alpha
chr17_+_42248073 0.870 NM_080863
ASB16
ankyrin repeat and SOCS box containing 16
chr17_-_1389013 0.869 NM_001080950
MYO1C
myosin IC
chr5_-_142065586 0.862 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr11_+_69467210 0.857 CCND1
cyclin D1
chr1_-_150978879 0.854 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr7_+_134212343 0.850 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr6_+_74405933 0.849 CD109
CD109 molecule
chr5_-_83016850 0.848 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr13_+_114321469 0.847 NM_002929
GRK1
G protein-coupled receptor kinase 1
chr9_-_21228132 0.845 NM_021268
IFNA17
interferon, alpha 17
chr11_+_65082288 0.843 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr1_-_205912546 0.836 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr7_-_113559048 0.836 NM_002711
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr19_-_53394598 0.836 NM_207333
ZNF320
zinc finger protein 320
chr1_+_74701070 0.834 NM_015978
TNNI3K
TNNI3 interacting kinase
chr14_-_94423766 0.827 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr12_+_81101407 0.824 NM_002469
MYF6
myogenic factor 6 (herculin)
chr4_-_65275000 0.816 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr14_+_24540742 0.814 NM_006032
CPNE6
copine VI (neuronal)
chr5_-_95748688 0.811 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr10_-_75415748 0.807 NM_001114133
SYNPO2L
synaptopodin 2-like
chr2_-_241080072 0.801 NM_148961
OTOS
otospiralin
chr3_-_149086884 0.799 TM4SF1
transmembrane 4 L six family member 1
chr10_+_135160843 0.789 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr2_+_228678556 0.770 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr2_-_165424993 0.769 GRB14
growth factor receptor-bound protein 14
chr10_-_43762366 0.749 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr2_-_235405692 0.748 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chrX_-_18690187 0.737 NM_000330
RS1
retinoschisin 1
chr11_-_18258315 0.730 SAA4
serum amyloid A4, constitutive
chr1_+_28585959 0.729 NM_031459
SESN2
sestrin 2
chr21_+_39628663 0.725 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_-_69455926 0.725 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_-_116383323 0.723 NM_001111061
NHLH2
nescient helix loop helix 2
chr6_-_123957941 0.723 NM_001251987
NM_006073
TRDN

triadin

chr6_-_48078909 0.722 C6orf138
chromosome 6 open reading frame 138
chr4_+_88896838 0.711 SPP1
secreted phosphoprotein 1
chr15_+_93443559 0.710 CHD2
chromodomain helicase DNA binding protein 2
chr20_+_44657858 0.709 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr2_+_102508377 0.709 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr19_-_46526555 0.705 NM_005091
PGLYRP1
peptidoglycan recognition protein 1
chr12_-_122240827 0.702


chr3_-_124842442 0.697 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr11_+_1860232 0.686 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr1_+_183114214 0.685 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr17_-_29648631 0.682 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr16_-_15833937 0.678 MYH11
myosin, heavy chain 11, smooth muscle
chr18_-_21242592 0.672 NM_173505
ANKRD29
ankyrin repeat domain 29
chr1_+_145413190 0.671 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr14_-_107131217 0.666 IGHA1
immunoglobulin heavy constant alpha 1
chr15_+_73976720 0.661 CD276
CD276 molecule
chr10_-_45474210 0.654 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr8_+_27631902 0.654 NM_001017420
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr8_+_87111132 0.650 NM_152565
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr19_+_8429010 0.645 NM_001039667
NM_139314
ANGPTL4

angiopoietin-like 4

chr6_+_27292539 0.640 NM_032030
FKSG83
FKSG83
chr6_+_152128453 0.636 NM_001122740
ESR1
estrogen receptor 1
chr10_-_75410778 0.636 NM_024875
SYNPO2L
synaptopodin 2-like
chr13_+_78109808 0.636 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr13_+_111137249 0.634 COL4A2
collagen, type IV, alpha 2
chr19_+_1026271 0.633 NM_004368
NM_201277
CNN2

calponin 2

chrX_+_106171328 0.632 CLDN2
claudin 2
chr2_+_169921298 0.631 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_+_80275634 0.631 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr11_-_105010460 0.631 NM_021571
CARD18
caspase recruitment domain family, member 18
chrX_+_123234462 0.630 STAG2
stromal antigen 2
chr5_+_155753755 0.628 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr7_-_44105162 0.624 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr6_+_34204690 0.623 HMGA1
high mobility group AT-hook 1
chr22_-_25777543 0.622 NM_001135772
LRP5L
low density lipoprotein receptor-related protein 5-like
chr7_+_110731061 0.609 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr3_-_57326709 0.607 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr5_+_175108463 0.605 NM_022304
HRH2
histamine receptor H2
chr1_-_19229016 0.600 NM_003748
NM_170726
ALDH4A1

aldehyde dehydrogenase 4 family, member A1

chr11_+_92085261 0.597 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr1_+_153003677 0.595 NM_003125
SPRR1B
small proline-rich protein 1B
chr19_-_52674895 0.594 NM_001102657
ZNF836
zinc finger protein 836
chr18_-_35145603 0.593 CELF4
CUGBP, Elav-like family member 4
chr2_-_211179765 0.592 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr3_+_36421944 0.591 NM_003149
STAC
SH3 and cysteine rich domain
chr19_-_15343194 0.590 NM_024794
EPHX3
epoxide hydrolase 3
chr2_-_106055229 0.589 NM_201557
FHL2
four and a half LIM domains 2
chr10_-_95241943 0.587 NM_013451
NM_133337
MYOF

myoferlin


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 2.60e-04 GO:0032501 multicellular organismal process
2.27 3.42e-02 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.82 4.60e-10 GO:0044421 extracellular region part
3.36 4.34e-07 GO:0030016 myofibril
3.27 4.90e-07 GO:0043292 contractile fiber
1.79 7.88e-07 GO:0005615 extracellular space
3.23 4.07e-06 GO:0044449 contractile fiber part
1.43 7.73e-06 GO:0005576 extracellular region
3.34 1.12e-05 GO:0030017 sarcomere
1.85 3.07e-02 GO:0015629 actin cytoskeleton
4.79 4.96e-02 GO:0001533 cornified envelope

Nothing significant found in function category.